This cluster of papers explores the therapeutic potential of herbal medicines, focusing on compounds such as Celastrol and Triptolide derived from Thunder God Vine and Tripterygium wilfordii Hook F. The research covers their applications in treating inflammatory disorders, cancer, and neurodegenerative diseases, as well as their potential in targeting specific pathways like NF-?B, inducing apoptosis, and acting as antioxidants. Additionally, the cluster delves into the use of these herbal medicines in conditions like rheumatoid arthritis through drug targeting approaches.