专题：Synthesis and pharmacology of benzodiazepine derivatives

This cluster of papers focuses on the chemistry, synthesis, and biological evaluation of pyrrolobenzodiazepines, a class of DNA-interactive agents with potent antitumour activity. The research covers topics such as asymmetric synthesis, cross-linking agents, cytotoxicity, and their application in natural product synthesis.
最新文献
Pyrrolobenzodiazepine Dimers for Chemotherapy and Antibody-Drug Conjugate Applications

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Recent developments in the synthesis of amidines

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Base-mediated Diastereoselective Synthesis of 2,3-Substituted Indolines via [4+1] Annulation

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Functionalized Indolizines as Potential Anticancer Agents: Synthetic, Biological and In Silico Investigations

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3-Hydroxyisoindolinones from Keto Acids and Amines: A Mild One-Pot Synthesis with Amidinium and Phosphonium Salts

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Review for "β-Carboline: a privileged scaffold from nature for potential antimalarial activity"

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Review for "β-Carboline: a privileged scaffold from nature for potential antimalarial activity"

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Review for "β-Carboline: a privileged scaffold from nature for potential antimalarial activity"

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Author response for "β-Carboline: a privileged scaffold from nature for potential antimalarial activity"

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Review for "β-Carboline: a privileged scaffold from nature for potential antimalarial activity"

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近5年高被引文献
Allopregnanolone: An overview on its synthesis and effects

review Full Text OpenAlex 74 FWCI2.351

Design, synthesis and molecular docking of new fused 1H-pyrroles, pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-e][1, 4]diazepine derivatives as potent EGFR/CDK2 inhibitors

article Full Text OpenAlex 49 FWCI4.754

Synthesis, molecular modelling study of the methaqualone analogues as anti-convulsant agent with improved cognition activity and minimized neurotoxicity

article Full Text OpenAlex 43 FWCI4.763

Synthesis of 3,3-Dialkyl-Substituted Isoindolinones Enabled by Nickel-Catalyzed Reductive Dicarbofunctionalization of Enamides

article Full Text OpenAlex 40 FWCI3.469

Bisindole natural products: A vital source for the development of new anticancer drugs

review Full Text OpenAlex 39 FWCI1.363

Skeletal remodeling of chalcone-based pyridinium salts to access isoindoline polycycles and their bridged derivatives

article Full Text OpenAlex 38 FWCI3.661

Recent Advances in the Direct Functionalization of Isoindolinones for the Synthesis of 3,3‐Disubstituted Isoindolinones

article Full Text OpenAlex 36 FWCI3.18

DNA-Compatible ortho-Phthalaldehyde (OPA)-Mediated 2-Substituted Isoindole Core Formation and Applications

article Full Text OpenAlex 32 FWCI3.456

Identification of harmine and β-carboline analogs from a high-throughput screen of an approved drug collection; profiling as differential inhibitors of DYRK1A and monoamine oxidase A and for in vitro and in vivo anti-cancer studies

article Full Text OpenAlex 31 FWCI2.179

Chiral Brønsted Acid Catalyzed Enantioselective Synthesis of Spiro-Isoindolinone-Indolines via Formal [3 + 2] Cycloaddition

article Full Text OpenAlex 31 FWCI3.456