专题:Synthesis and pharmacology of benzodiazepine derivatives

This cluster of papers focuses on the chemistry, synthesis, and biological evaluation of pyrrolobenzodiazepines, a class of DNA-interactive agents with potent antitumour activity. The research covers topics such as asymmetric synthesis, cross-linking agents, cytotoxicity, and their application in natural product synthesis.
最新文献
Zur Kenntnis der Indolo[2,3-d]tropone und Indolo[2,3-d]tropolone

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Furo‐/Thieno[2,3‐ c ]pyridine Derivatives: Synthesis, Reactions, and Applications

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Synthesis and application of alkylstannatranes: Versatile precursors for C(sp 3 )-C(sp 2 ) cross-coupling

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A Feasible Synthesis of Benzimidazonaphthyridines Involving Suzuki and C–N Cross-Coupling Reactions

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Efficient Syntheses of Indolizine‐3‐Phosphonates via Pyridinium Ylide [3+2] Reactions

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Copper-catalyzed synthesis of benzo[1,4]diazepinoindoles/carbazoles via two sequential Ullmann coupling reactions

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Developing new accesses to silylated and germylated heterocycles: an overview

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Fused Indole-Diazepines with a Bridgehead Nitrogen Atom: Synthesis and Pharmaceutical Significance

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BENZO[f][1,2,4]TRIAZINO[2,3-d][1,4]DIAZEPINES – A NEW HETEROCYCLIC SYSTEM: SYNTHESIS AND SPECTRAL CHARACTERISTICS

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Bioinspired Alkyl Transfer Enabled by Ca(II)/HFIP Cooperative Catalysis: Modular Synthesis of Functionalized Isoindolinones

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近5年高被引文献
Bisindole natural products: A vital source for the development of new anticancer drugs

review Full Text OpenAlex 70 FWCI4.687

Design, synthesis and molecular docking of new fused 1 H -pyrroles, pyrrolo[3,2- d ]pyrimidines and pyrrolo[3,2- e ][1, 4]diazepine derivatives as potent EGFR/CDK2 inhibitors

article Full Text OpenAlex 64 FWCI5.1208

Photochemical Deracemization of 4,7-Diaza-1-isoindolinones by Unidirectional Hydrogen Atom Shuttling

article Full Text OpenAlex 56 FWCI11.0005

Chiral Brønsted Acid Catalyzed Enantioselective Synthesis of Spiro-Isoindolinone-Indolines via Formal [3 + 2] Cycloaddition

article Full Text OpenAlex 45 FWCI4.8255

Cobalt‐Catalyzed Enantioselective C−H Carbonylation towards Chiral Isoindolinones

article Full Text OpenAlex 43 FWCI10.1376

DNA-Compatible ortho-Phthalaldehyde (OPA)-Mediated 2-Substituted Isoindole Core Formation and Applications

article Full Text OpenAlex 38 FWCI3.9481

A review on the chemistry and pharmacological properties of benzodiazepine motifs in drug design

review Full Text OpenAlex 37 FWCI3.5095

Synthesis, anticancer for prostate cancer cells and antibacterial activity of new diazepine derivatives

article Full Text OpenAlex 32 FWCI4.8331

Copper-catalyzed direct synthesis of 3-methylene-2-arylisoindolin-1-ones with calcium carbide as a surrogate of gaseous acetylene

article Full Text OpenAlex 32 FWCI4.6762

Cryptolepine Targets TOP2A and Inhibits Tumor Cell Proliferation in Breast Cancer Cells -An In vitroandIn silicoStudy

article Full Text OpenAlex 31 FWCI2.6866