专题：Synthesis and pharmacology of benzodiazepine derivatives

This cluster of papers focuses on the chemistry, synthesis, and biological evaluation of pyrrolobenzodiazepines, a class of DNA-interactive agents with potent antitumour activity. The research covers topics such as asymmetric synthesis, cross-linking agents, cytotoxicity, and their application in natural product synthesis.
最新文献
The 1,5-Benzodiazepin-2-Ones: A Review on Synthetic Strategies, Reactivity and Functional Applications

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Fully Reversible Photocontrol over DNA Intercalation with Visible Light

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Rational Use of Benzodiazepines in Modern Healthcare: Evidence-Based Strategies

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Synthesis of 2, 4-disubstituted-1 H -benzo[ b ][1,4]diazepine derivatives as promising anticancer agents

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Ruthenium( ii ) polypyridyl complexes and the DNA damage response: mechanisms and therapeutic implications

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An enduring threat: NPS benzodiazepines in forensic and clinical toxicology from 2021 to 2025

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BENZO[f][1,2,4]TRIAZINO[2,3-d][1,4]DIAZEPINES – A NEW HETEROCYCLIC SYSTEM: SYNTHESIS AND SPECTRAL CHARACTERISTICS

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Antibody–Drug Conjugates (ADCs): A Review of Structural Design, Technological Evolution, and Future Perspectives

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Alkylating agents in cancer: Current developments

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Crystal Structures, Hirshfeld Surface Analysis, Interaction Energies and Molecular Docking Studies of New 2(E)-Pyranylidene-1,5-Benzodiazepine Derivatives

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近5年高被引文献
Antibody–drug conjugates: Recent advances in payloads

article Full Text OpenAlex 263 FWCI38.7648

Benzodiazepines Remain Important Therapeutic Options in Psychiatric Practice

article Full Text OpenAlex 171 FWCI28.6549

The Evolving Landscape of Antibody–Drug Conjugates: In Depth Analysis of Recent Research Progress

article Full Text OpenAlex 154 FWCI22.5486

Mechanism-based design of agents that selectively target drug-resistant glioma

article Full Text OpenAlex 121 FWCI11.7923

The recent developments of camptothecin and its derivatives as potential anti-tumor agents

article Full Text OpenAlex 118 FWCI8.8013

Dearomatization of Pyridines: Photochemical Skeletal Enlargement for the Synthesis of 1,2-Diazepines

article Full Text OpenAlex 109 FWCI14.8598

Topoisomerase I inhibitors: Challenges, progress and the road ahead

article Full Text OpenAlex 108 FWCI5.455

DNA Alkylation Damage by Nitrosamines and Relevant DNA Repair Pathways

article Full Text OpenAlex 104 FWCI7.7144

Linker Design for the Antibody Drug Conjugates: A Comprehensive Review

article Full Text OpenAlex 68 FWCI35.7362

Three's a crowd – stabilisation, structure, and applications of DNA triplexes

article Full Text OpenAlex 68 FWCI3.5183