专题：Synthesis and pharmacology of benzodiazepine derivatives

This cluster of papers focuses on the chemistry, synthesis, and biological evaluation of pyrrolobenzodiazepines, a class of DNA-interactive agents with potent antitumour activity. The research covers topics such as asymmetric synthesis, cross-linking agents, cytotoxicity, and their application in natural product synthesis.
最新文献
Brivaracetam (amtiepileptic) synthesis

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The selectivity of the (3+2) cycloaddition of 1-bromo-1-(ethoxycarbonylmethylidene)-2-nitrophenylhydrazine to 1-methyl-4-phenyl-1,3-dihydro-2H-1,5-benzodiazepine-2-thione and the bioevaluation of the reaction products

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Enantioselective Synthesis of Spiro-bis-N-heterocyclic Lactams via Formal (3+2) Cycloaddition of 3-Methylene Isoindolinones with C3-Substituted 2-Indolylmethanols

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Computation and experimental investigation of halogenated 2,3-dihydrobenzo[b][1,4]thiazepine: XRD, DFT and NCIanalysis

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Photostability of Topoisomerase I Inhibitor Conjugated IgG1 Antibody–Drug Conjugates: Characterization Study and Degradation Mechanism Analysis

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Skleton rearrangement to prepare spirooxindolequinazolone

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Design, synthesis, and pharmacological evaluation of novel isoindoline-based HPK1 degraders

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Concluding Remarks and Future Perspectives on Semi-Aromatic Quinoline Derivatives

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NPAH formation through ring expansion: Indole formation from acetylene addition to pyrrole

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Fluphenazine Decanoate: First-Generation Antipsychotic Long-Acting Injectable

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近5年高被引文献
Allopregnanolone: An overview on its synthesis and effects

review Full Text OpenAlex 88 FWCI7.03649196

Design, synthesis and molecular docking of new fused 1 H -pyrroles, pyrrolo[3,2- d ]pyrimidines and pyrrolo[3,2- e ][1, 4]diazepine derivatives as potent EGFR/CDK2 inhibitors

article Full Text OpenAlex 59 FWCI7.26108032

Bisindole natural products: A vital source for the development of new anticancer drugs

review Full Text OpenAlex 52 FWCI6.27652706

Synthesis, molecular modelling study of the methaqualone analogues as anti-convulsant agent with improved cognition activity and minimized neurotoxicity

article Full Text OpenAlex 45 FWCI5.92340843

Chiral Brønsted Acid Catalyzed Enantioselective Synthesis of Spiro-Isoindolinone-Indolines via Formal [3 + 2] Cycloaddition

article Full Text OpenAlex 44 FWCI7.565706

Synthesis of 3,3-Dialkyl-Substituted Isoindolinones Enabled by Nickel-Catalyzed Reductive Dicarbofunctionalization of Enamides

article Full Text OpenAlex 42 FWCI4.77669874

Recent Advances in the Direct Functionalization of Isoindolinones for the Synthesis of 3,3‐Disubstituted Isoindolinones

article Full Text OpenAlex 41 FWCI4.37864051

Skeletal remodeling of chalcone-based pyridinium salts to access isoindoline polycycles and their bridged derivatives

article Full Text OpenAlex 41 FWCI5.04207089

Cobalt‐Catalyzed Enantioselective C−H Carbonylation towards Chiral Isoindolinones

article Full Text OpenAlex 39 FWCI16.99171853

Identification of harmine and β-carboline analogs from a high-throughput screen of an approved drug collection; profiling as differential inhibitors of DYRK1A and monoamine oxidase A and for in vitro and in vivo anti-cancer studies

article Full Text OpenAlex 37 FWCI3.02350524