专题：Synthesis and pharmacology of benzodiazepine derivatives

This cluster of papers focuses on the chemistry, synthesis, and biological evaluation of pyrrolobenzodiazepines, a class of DNA-interactive agents with potent antitumour activity. The research covers topics such as asymmetric synthesis, cross-linking agents, cytotoxicity, and their application in natural product synthesis.
最新文献
Synthesis and in Vitro Evaluation of Neurotoxicity and MAOA/B Inhibitory Effects of New Pyrrolyl-Based Furan, Substituted Furan and Indole Azomethine Derivates

article Full Text OpenAlex

Application of the intramolecular Diels-Alder vinylarene (IMDAV) reaction for the synthesis of benzo-and carbocyclofuroisoindolecarboxylic acids and its limitations

article Full Text OpenAlex

Palladium-Catalyzed Tandem Synthesis of Fused Spiroquinolinones from Bicyclobutyl Amides

article Full Text OpenAlex

Vicinal difuctionalization of 3-([1,1′-biphenyl]-2-yl)-N-alklypyridin-2(1H)-ones via photocascade reaction

article Full Text OpenAlex

Novel Phenethylamine-Based Aroyl Thiourea Derivatives: Design, Synthesis, and Multibiological Evaluation

article Full Text OpenAlex

Synthesis of novel isocoumarin–3-yl ethylidene malononitrile and isocoumarin–thiophene hybrid compounds: spectroscopic characterization and theoretical investigation

article Full Text OpenAlex

Design, Synthesis and Evaluation of Phthalimide and Its Derivatives

article Full Text OpenAlex

Skeletal Editing of Benzocyclobutenols toward Beonzo[b]furans

article Full Text OpenAlex

Design, Synthesis and Evaluation of Phthalimide and Its Derivatives

article Full Text OpenAlex

Sequential Ag(I)/Pd(0) Relay Catalysis Toward (4+3) Oxadiazepine Cycloadducts

article Full Text OpenAlex

近5年高被引文献
Bisindole natural products: A vital source for the development of new anticancer drugs

review Full Text OpenAlex 63 FWCI4.6887

Design, synthesis and molecular docking of new fused 1 H -pyrroles, pyrrolo[3,2- d ]pyrimidines and pyrrolo[3,2- e ][1, 4]diazepine derivatives as potent EGFR/CDK2 inhibitors

article Full Text OpenAlex 62 FWCI5.0609

Chiral Brønsted Acid Catalyzed Enantioselective Synthesis of Spiro-Isoindolinone-Indolines via Formal [3 + 2] Cycloaddition

article Full Text OpenAlex 45 FWCI4.7849

Cobalt‐Catalyzed Enantioselective C−H Carbonylation towards Chiral Isoindolinones

article Full Text OpenAlex 40 FWCI10.4864

DNA-Compatible ortho-Phthalaldehyde (OPA)-Mediated 2-Substituted Isoindole Core Formation and Applications

article Full Text OpenAlex 38 FWCI3.9352

A review on the chemistry and pharmacological properties of benzodiazepine motifs in drug design

review Full Text OpenAlex 36 FWCI3.4979

Synthesis, anticancer for prostate cancer cells and antibacterial activity of new diazepine derivatives

article Full Text OpenAlex 32 FWCI4.9006

Copper-catalyzed direct synthesis of 3-methylene-2-arylisoindolin-1-ones with calcium carbide as a surrogate of gaseous acetylene

article Full Text OpenAlex 31 FWCI4.7768

Transition metal-free advanced synthetic approaches for isoindolinones and their fused analogues

article Full Text OpenAlex 30 FWCI2.9514

RETRACTED: Mechanochemically Induced Dehydrogenation Coupling and [3+2] Cycloaddition of Indolizines with Allenes Using Piezoelectric Materials

article Full Text OpenAlex 29 FWCI3.1538