专题：Synthesis and bioactivity of alkaloids

This cluster of papers focuses on the biochemical, pharmacological, and therapeutic functions of beta-carboline alkaloids such as harmine and cryptolepine. The research covers a wide range of topics including their anticancer, antimalarial, DNA binding, antioxidant, and cytotoxic properties.
最新文献
Harnessing the Quinoline Scaffold toward Discovery and Development of Antimalarials

review Full Text OpenAlex

Precision indole skeletal editing for single-carbon replacement

article Full Text OpenAlex

Tryptanthrin: Synthetic advances and therapeutic horizons of a privileged scaffold

review Full Text OpenAlex

Ayahuasca and Its Main Component N,N-Dimethyltryptamine (DMT) for the Treatment of Mental Disorders: Mechanisms of Action, Clinical Studies, and Tools to Explore the Human Mind

review Full Text OpenAlex

Natural Alkaloids as Antiviral Agents Against RNA Viruses: A Comprehensive and Mechanistic Review

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Synthetic strategies and therapeutic insights into FDA-approved indole-containing drugs

review Full Text OpenAlex

Natural product scaffold‐based bactericide discovery: novel β‐carboline derivatives as potent reactive oxygen species inducers for crop disease control

article Full Text OpenAlex

Bacteria from foods and gut microbiota produce methylglyoxal and this metabolite leads to the formation of bioactive 1-acetyl-β-carboline alkaloids

article Full Text OpenAlex

Discovery, bioactivities and biosynthesis of spirooxindole alkaloids

review Full Text OpenAlex

Regio- and Enantioselective Pictet–Spengler Reaction of α-Diketones Catalyzed by a Single H-Bond Donor Organocatalyst

article Full Text OpenAlex

近5年高被引文献
Target-based anticancer indole derivatives and insight into structure‒activity relationship: A mechanistic review update (2018–2021)

review Full Text OpenAlex 192 FWCI3.882

Anti-trypanosomatid drug discovery: progress and challenges

review Full Text OpenAlex 173 FWCI5.7761

Indole-Containing Natural Products 2019–2022: Isolations, Reappraisals, Syntheses, and Biological Activities

review Full Text OpenAlex 152 FWCI3.1013

Therapeutic Outcomes of Isatin and Its Derivatives against Multiple Diseases: Recent Developments in Drug Discovery

review Full Text OpenAlex 131 FWCI2.4789

Indole Derivatives: A Versatile Scaffold in Modern Drug Discovery—An Updated Review on Their Multifaceted Therapeutic Applications (2020–2024)

review Full Text OpenAlex 130 FWCI5.3264

Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets

review Full Text OpenAlex 121 FWCI2.7805

Pharmacological properties of indirubin and its derivatives

article Full Text OpenAlex 107 FWCI11.8259

Alkaloids as potential antivirals. A comprehensive review

review Full Text OpenAlex 103 FWCI4.916

Potential Antiviral Action of Alkaloids

review Full Text OpenAlex 100 FWCI3.3642

Novel thiosemicarbazide-based β-carboline derivatives as α-glucosidase inhibitors: Synthesis and biological evaluation

article Full Text OpenAlex 90 FWCI24.0478