This cluster of papers focuses on the clinical, genetic, and therapeutic aspects of autoinflammatory bone disorders, including chronic recurrent multifocal osteomyelitis (CRMO), synovitis acne pustulosis hyperostosis osteitis (SAPHO) syndrome, and non-bacterial osteomyelitis. It explores the role of genetic mutations, the efficacy of biological therapies such as pamidronate, and the use of advanced imaging techniques in diagnosis and management.