专题：Calcium signaling and nucleotide metabolism

This cluster of papers explores the evolution, function, and dysregulation of lysosomal calcium signaling, focusing on the role of two-pore channels, NAADP, TRPML1, and cyclic ADP-ribose in intracellular calcium release and endolysosomal trafficking. It also investigates the implications of these mechanisms in diseases such as mucolipidosis type IV and lysosomal storage disorders.
最新文献
Lysosomal polyamine storage upon ATP13A2 loss impairs β-glucocerebrosidase via altered lysosomal pH and electrostatic hydrolase-lipid interactions

article Full Text OpenAlex

LYVAC/PDZD8 is a lysosomal vacuolator

article Full Text OpenAlex

LCMS/MS-based mining of the peptaibiome: A discovery of new peptaibols

preprint Full Text OpenAlex

TCF25 serves as a nutrient sensor to orchestrate metabolic adaptation and cell death by enhancing lysosomal acidification under glucose starvation

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A protein tunnel helps stressed lysosomes swell

article Full Text OpenAlex

8-OXO-Cordycepin Is Not a Suitable Substrate for Adenosine Deaminase-Preliminary Experimental and Theoretical Studies

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PKD3 localizes to late endosomes to maintain Rab7-dependent endolysosomal homeostasis.

article Full Text OpenAlex

Glycoproteomics analysis of complement factor H and its complement-regulatory function during Streptococcus pneumoniae-associated hemolytic uremic syndrome

article Full Text OpenAlex

Epimedokoreanin B blocks autophagic flux to inhibit progression of triple negative breast cancer through targeting MCOLN1/TRPML1 channel

article Full Text OpenAlex

Prognostic and clinicopathological significance of TRPM8 in various cancers: a meta and bioinformatic analysis

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近5年高被引文献
Regulation of SIRT1 and Its Roles in Inflammation

review Full Text OpenAlex 453 FWCI21.097

Low-dose metformin targets the lysosomal AMPK pathway through PEN2

article Full Text OpenAlex 426 FWCI40.845

Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia

article Full Text OpenAlex 409 FWCI24.922

NAD+ metabolism, stemness, the immune response, and cancer

review Full Text OpenAlex 368 FWCI10.907

Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation

review Full Text OpenAlex 364 FWCI27.911

Lysosome biogenesis: Regulation and functions

review Full Text OpenAlex 335 FWCI11.519

An overview of autophagy: Mechanism, regulation and research progress

review Full Text OpenAlex 331 FWCI11.823

Mechanisms of Selective Autophagy

review Full Text OpenAlex 319 FWCI10.606

Autophagy in tumour immunity and therapy

review Full Text OpenAlex 315 FWCI11.649

The emerging mechanisms and functions of microautophagy

review Full Text OpenAlex 304 FWCI15.833