专题：Calcium signaling and nucleotide metabolism

This cluster of papers explores the evolution, function, and dysregulation of lysosomal calcium signaling, focusing on the role of two-pore channels, NAADP, TRPML1, and cyclic ADP-ribose in intracellular calcium release and endolysosomal trafficking. It also investigates the implications of these mechanisms in diseases such as mucolipidosis type IV and lysosomal storage disorders.
最新文献
Metabolic regulation by tanycyte-derived extracellular vesicles through insulin precursor-mediated neuronal recognition and mTORC component delivery

article Full Text OpenAlex

Spatiotemporal regulation of endocytic membrane trafficking by voltage-sensing phosphatase (VSP) in zebrafish enterocytes

article Full Text OpenAlex

TMEM55B—Jack of all trades in the endo-lysosomal system?

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Intravenous infusion of nicotinamide adenine dinucleotide (NAD+) versus nicotinamide riboside (NR): a retrospective tolerability pilot study in a real-world setting

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CD38 endows local antigen-specific Treg cells with stress resilience for control of compartmentalized CNS inflammation

article Full Text OpenAlex

De novo design of potent CRISPR–Cas13 inhibitors

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The lever model of synaptotagmin-1 function

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Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder

article Full Text OpenAlex

Extracellular vesicles in Niemann pick disease type C: current knowledge and future opportunities

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DNA nanodevices detect an acidic nanolayer on the lysosomal surface

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近5年高被引文献
Regulation of SIRT1 and Its Roles in Inflammation

review Full Text OpenAlex 609 FWCI73.6219

Low-dose metformin targets the lysosomal AMPK pathway through PEN2

article Full Text OpenAlex 572 FWCI47.1887

Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation

review Full Text OpenAlex 551 FWCI120.0152

Mitophagy in human health, ageing and disease

review Full Text OpenAlex 450 FWCI98.016

The emerging mechanisms and functions of microautophagy

review Full Text OpenAlex 430 FWCI65.1737

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

review Full Text OpenAlex 412 FWCI85.2432

Phosphoinositides as membrane organizers

review Full Text OpenAlex 399 FWCI56.2793

A phosphoinositide signalling pathway mediates rapid lysosomal repair

article Full Text OpenAlex 333 FWCI36.0678

Autophagy: A Key Regulator of Homeostasis and Disease: An Overview of Molecular Mechanisms and Modulators

review Full Text OpenAlex 323 FWCI46.47

DAMPs and DAMP-sensing receptors in inflammation and diseases

review Full Text OpenAlex 320 FWCI79.1923