专题：Calcium signaling and nucleotide metabolism

This cluster of papers explores the evolution, function, and dysregulation of lysosomal calcium signaling, focusing on the role of two-pore channels, NAADP, TRPML1, and cyclic ADP-ribose in intracellular calcium release and endolysosomal trafficking. It also investigates the implications of these mechanisms in diseases such as mucolipidosis type IV and lysosomal storage disorders.
最新文献
Anti-CD38/Anti-CD20 Rescue Therapy for Posttransplant Recurrent FSGS

article Full Text OpenAlex

Beyond α-GalCer: Medicinal Chemistry Insights Driving Structural Evolution of CD1d Ligands

article Full Text OpenAlex

Design of Inhibitory Peptides Based on TRPM4-KCTD5 Interaction

article Full Text OpenAlex

CRISPR-Cas Systems

book-chapter Full Text OpenAlex

Novel autophagy-promoted cancer therapy: Discovery of matrine-based selective TBC1D2 inhibitors by drug-target complex purification

article Full Text OpenAlex

Human whole-blood NAD+ levels do not vary with age or lifestyle interventions

article Full Text OpenAlex

Rheumatoid Arthritis: A Comprehensive Review of Etiology, Pathophysiology, and Innovative Therapeutic Advancements

article Full Text OpenAlex

Comparative insights into the apoptosome, inflammasomes and PIDDosome

article Full Text OpenAlex

Voltage-gated potassium channels as important modulators of glucose-stimulated insulin secretion in pancreatic β-cells: insights from rodent and human studies

article Full Text OpenAlex

Peroxisome-derived ether lipids regulate lysosomal exocytosis

article Full Text OpenAlex

近5年高被引文献
Regulation of SIRT1 and Its Roles in Inflammation

review Full Text OpenAlex 664 FWCI72.2522

Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation

review Full Text OpenAlex 637 FWCI122.5908

Low-dose metformin targets the lysosomal AMPK pathway through PEN2

article Full Text OpenAlex 615 FWCI45.5741

Mitophagy in human health, ageing and disease

review Full Text OpenAlex 547 FWCI105.1513

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

review Full Text OpenAlex 480 FWCI82.6784

The emerging mechanisms and functions of microautophagy

review Full Text OpenAlex 462 FWCI64.5722

Phosphoinositides as membrane organizers

review Full Text OpenAlex 446 FWCI53.5034

DAMPs and DAMP-sensing receptors in inflammation and diseases

review Full Text OpenAlex 430 FWCI83.4633

Autophagy: A Key Regulator of Homeostasis and Disease: An Overview of Molecular Mechanisms and Modulators

review Full Text OpenAlex 378 FWCI45.9709

A phosphoinositide signalling pathway mediates rapid lysosomal repair

article Full Text OpenAlex 367 FWCI35.1609