专题：Calcium signaling and nucleotide metabolism

This cluster of papers explores the evolution, function, and dysregulation of lysosomal calcium signaling, focusing on the role of two-pore channels, NAADP, TRPML1, and cyclic ADP-ribose in intracellular calcium release and endolysosomal trafficking. It also investigates the implications of these mechanisms in diseases such as mucolipidosis type IV and lysosomal storage disorders.
最新文献
TMEM175 does not function as a proton-selective ion channel to prevent lysosomal over-acidification

article Full Text OpenAlex

The multifaceted phosphatidylinositol 5 phosphate 4-kinase proteins: molecular properties and biological functions

article Full Text OpenAlex

SIK2-mediated phosphorylation of GABARAPL2 facilitates autophagosome–lysosome fusion and rescues neurodegeneration in an Alzheimer’s disease model

article Full Text OpenAlex

Anticancer Activity of Triterpene Glycosides Cucumarioside A0-1 and Djakonovioside A Against MDA-MB-231 as A2B Adenosine Receptor Antagonists

article Full Text OpenAlex

Visualization of lysosomal membrane proteins by cryo electron tomography

article Full Text OpenAlex

The multifaceted roles of NAD+ in bacterial immunity

review Full Text OpenAlex

Pramipexole improves cognitive deficits and synaptic plasticity impairments in 3xTg-AD mice through enhancing autophagy

article Full Text OpenAlex

The multifaceted role of autophagy and mitophagy in cardiovascular health and disease

review Full Text OpenAlex

A phosphoinositide switch from PI(4,5)P 2 to PI4P triggers endocytosis by inducing dynamin-mediated fission in secretory cells

article Full Text OpenAlex

NAD+ precursor supplementation in human ageing: clinical evidence and challenges

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近5年高被引文献
Regulation of SIRT1 and Its Roles in Inflammation

review Full Text OpenAlex 575 FWCI107.82149338

Low-dose metformin targets the lysosomal AMPK pathway through PEN2

article Full Text OpenAlex 539 FWCI66.58041447

Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation

review Full Text OpenAlex 502 FWCI177.23330702

The emerging mechanisms and functions of microautophagy

review Full Text OpenAlex 406 FWCI93.58381068

Mitophagy in human health, ageing and disease

review Full Text OpenAlex 385 FWCI135.92594263

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

review Full Text OpenAlex 380 FWCI106.06810389

Phosphoinositides as membrane organizers

review Full Text OpenAlex 370 FWCI75.1814967

A phosphoinositide signalling pathway mediates rapid lysosomal repair

article Full Text OpenAlex 314 FWCI50.4439912

Autophagy: A Key Regulator of Homeostasis and Disease: An Overview of Molecular Mechanisms and Modulators

review Full Text OpenAlex 296 FWCI66.20437446

DAMPs and DAMP-sensing receptors in inflammation and diseases

review Full Text OpenAlex 280 FWCI134.03166896