专题：Calcium signaling and nucleotide metabolism

This cluster of papers explores the evolution, function, and dysregulation of lysosomal calcium signaling, focusing on the role of two-pore channels, NAADP, TRPML1, and cyclic ADP-ribose in intracellular calcium release and endolysosomal trafficking. It also investigates the implications of these mechanisms in diseases such as mucolipidosis type IV and lysosomal storage disorders.
最新文献
BLOC1S1 variants cause lysosomal and autophagic defects resulting in a hypomyelinating leukodystrophy with epileptic encephalopathy

article Full Text OpenAlex

Exosome-like nanovesicles from acerola for CRISPR-Cas9 ribonucleoprotein delivery to the central nervous system

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Natural Products Targeting PAD4 in NETosis: Structural and Mechanistic Insights into Direct and Indirect Inhibition

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Comparison of neonatal systemic and intracerebroventricular AAV9 gene therapy delivery demonstrating improved behavioral and phenotypic outcomes in a mouse model of Niemann-Pick disease, type C1

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NLRP3 acts as a direct sensor of intracellular potassium ions

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Mechanoresilience of lysosomes conferred by TMEM63A

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Endosomal actin attenuation and fission are regulated by MICAL2

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NAD⁺ as a central metabolic hub Regulating the hallmarks of aging: Mechanisms and therapeutic implications

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The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities

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Molecularly Encoded Rohitukine-Derived pH-Responsive Carbon Dots for Mercury Ion Sensing, Anticounterfeiting, and Live-Cell Imaging

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近5年高被引文献
Regulation of SIRT1 and Its Roles in Inflammation

review Full Text OpenAlex 632 FWCI73.5658

Low-dose metformin targets the lysosomal AMPK pathway through PEN2

article Full Text OpenAlex 597 FWCI47.1401

Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation

review Full Text OpenAlex 597 FWCI124.0735

Mitophagy in human health, ageing and disease

review Full Text OpenAlex 498 FWCI103.1506

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

review Full Text OpenAlex 454 FWCI87.9057

The emerging mechanisms and functions of microautophagy

review Full Text OpenAlex 446 FWCI65.694

Phosphoinositides as membrane organizers

review Full Text OpenAlex 428 FWCI56.1086

DAMPs and DAMP-sensing receptors in inflammation and diseases

review Full Text OpenAlex 365 FWCI80.8877

A phosphoinositide signalling pathway mediates rapid lysosomal repair

article Full Text OpenAlex 354 FWCI35.9961

Autophagy: A Key Regulator of Homeostasis and Disease: An Overview of Molecular Mechanisms and Modulators

review Full Text OpenAlex 347 FWCI46.8722