This cluster of papers explores the concept of Smart University within the context of Digital Ecosystems, focusing on topics such as Internet of Things, Artificial Intelligence, cognitive modeling, educational technology, innovation management, predictive maintenance, knowledge management, and industrial control systems. The papers discuss the principles and semantics of digital ecosystems, machine learning algorithms for smart data analysis, ontology of smart classrooms, mobile social networking for smart campuses, and the development and evaluation models for smart universities.