专题:Synthesis of β-Lactam Compounds

This cluster of papers focuses on the synthesis, stereocontrolled synthesis, and applications of ß-lactams, including their use as building blocks for various biologically active compounds such as anticancer agents and cholesterol absorption inhibitors. The research also delves into asymmetric catalysis, enantioselective synthesis, and the Kinugasa reaction for the production of these versatile compounds.
最新文献
Pharmacokinetics and pre-systemic biotransformation of a deuterated clopidogrel-ferulic acid conjugate in rats

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Precipitation Inhibitor–Stabilized Supersaturated SNEDDS of Ticagrelor: Design, Optimization, and Pharmacokinetic Study

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POSTER: MM-1377 Balancing Efficacy and Safety: Apixaban vs Rivaroxaban in Multiple Myeloma-Associated Thrombosis and Clinical Outcomes

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Structurally Divergent Reactivity of 2,2-Disubstituted Azetidines – Mechanistic Insights and Stereochemical Implications of Amide Coupling and Ring Expansion to 5,6-dihydro-4H-1,3-oxazines

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Antithrombotic Potential of Lornoxicam; Possible Mechanistic Pathways

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POSTER: MM-1157 Trial in Progress: Quintessential—A Phase 2 Study of Arlocabtagene Autoleucel in Triple- and Quad-Class Exposed Patients With Relapsed and Refractory Multiple Myeloma

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Effects of celecoxib combined with glucosamine hydrochloride in the management of knee osteoarthritis

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Chiral Ammonium Salt Catalyzed Synthesis of α-Tertiary Amines from Alkynyl Ketimines

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Synthesis of 3-Azetidinones through Light-Driven C–C Bond Formation

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Highly Selective Azetidine Synthesis by Boryl Allylation of Azetines

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近5年高被引文献
Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective

review Full Text OpenAlex 180 FWCI9.176

Recent advances in the synthesis and reactivity of azetidines: strain-driven character of the four-membered heterocycle

review Full Text OpenAlex 96 FWCI1.685

Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies

article Full Text OpenAlex 86 FWCI9.587

Discovery of new anticancer thiourea-azetidine hybrids: design, synthesis, in vitro antiproliferative, SAR, in silico molecular docking against VEGFR-2, ADMET, toxicity, and DFT studies

article Full Text OpenAlex 75 FWCI6.648

Medicinal chemistry perspectives of 1,2,3,4-tetrahydroisoquinoline analogs – biological activities and SAR studies

review Full Text OpenAlex 73 FWCI2.028

A review: FDA-approved fluorine-containing small molecules from 2015 to 2022

review Full Text OpenAlex 70 FWCI2.82

Visible‐Light‐Induced Cycloaddition of α‐Ketoacylsilanes with Imines: Facile Access to β‐Lactams

article Full Text OpenAlex 59 FWCI4.818

Modular Synthesis of α‐Quaternary Chiral β‐Lactams by a Synergistic Copper/Palladium‐Catalyzed Multicomponent Reaction

article Full Text OpenAlex 59 FWCI5.203

Heterocyclic pyrimidine derivatives as promising antibacterial agents

review Full Text OpenAlex 56 FWCI2.848

Azetidines of pharmacological interest

review Full Text OpenAlex 53 FWCI0.899