专题:Synthesis of β-Lactam Compounds

This cluster of papers focuses on the synthesis, stereocontrolled synthesis, and applications of ß-lactams, including their use as building blocks for various biologically active compounds such as anticancer agents and cholesterol absorption inhibitors. The research also delves into asymmetric catalysis, enantioselective synthesis, and the Kinugasa reaction for the production of these versatile compounds.
最新文献
Designing the Next Generation of Antibiotics: Structure, SAR, and Strategy in Medicinal Chemistry (2000–2025)

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[2+2] Photocycloaddition reactions of sulfinylamines with alkenes to access β-sultam derivatives

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Bay 11-7082 Potentiates Select β -Lactams to Inhibit Growth of Methicillin-Resistant Staphylococcus aureus

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Copolymers of 2,2-Diallyl-1,1,3,3-tetraethylguanidinium Chloride with Ethylene Glycol Vinyl Ether and Their Functionalization by Biologically Active Acids

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Union of the in situ Generated ortho-Quinone Methides (o-QMs) with Azabicyclo[1.1.0]butanes (ABB) towards the Synthesis of Functionalized Azetidines

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New Pyridinium Salt Bioconjugates of Cholesterol and Methylpyridine Derivatives: Synthesis and Characterization

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Biosynthesis of fosfomycin-loaded CuO nanoparticles: evaluation of antibacterial, antibiofilm properties and molecular docking analysis against biofilm-associated proteins in MDR bacteria

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Union of the in situ Generated ortho-Quinone Methides (o-QMs) with Azabicyclo[1.1.0]butanes (ABB) towards the Synthesis of Functionalized Azetidines

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Visible-light-induced diastereoselective synthesis of β-lactams via a Cu( i )-catalyzed cascade 1,5-H shift/cyclization

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Leveraging Catalysis for Synthetic Innovation in β-Lactams: Advances from 2016 to 2026

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近5年高被引文献
Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective

review Full Text OpenAlex 307 FWCI44.3625

A review: FDA-approved fluorine-containing small molecules from 2015 to 2022

review Full Text OpenAlex 115 FWCI12.3898

Indole-containing pharmaceuticals: targets, pharmacological activities, and SAR studies

review Full Text OpenAlex 105 FWCI23.0239

Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies

article Full Text OpenAlex 97 FWCI10.2024

CYP2C19 Genetic Testing for Oral P2Y12 Inhibitor Therapy: A Scientific Statement From the American Heart Association

review Full Text OpenAlex 93 FWCI35.9841

Heterocyclic pyrimidine derivatives as promising antibacterial agents

review Full Text OpenAlex 78 FWCI11.2712

2-Oxabicyclo[2.2.2]octane as a new bioisostere of the phenyl ring

article Full Text OpenAlex 55 FWCI7.9212

Complexes of β-lactam antibiotics and their Schiff-base derivatives as a weapon in the fight against bacterial resistance

article Full Text OpenAlex 50 FWCI7.3066

Celecoxib-Loaded Solid Lipid Nanoparticles for Colon Delivery: Formulation Optimization and In Vitro Assessment of Anti-Cancer Activity

article Full Text OpenAlex 48 FWCI4.1032

Fifty years with aspirin and platelets

review Full Text OpenAlex 47 FWCI8.194