专题：Apelin-related biomedical research

This cluster of papers explores the role of apelin, a novel adipokine, and its receptor APJ in various physiological processes such as cardiovascular regulation, angiogenesis, obesity, diabetes, and neuroprotection. The research covers molecular properties, tissue distribution, signaling pathways, therapeutic potential, and pathophysiological implications of the apelin/APJ system.
最新文献
CKDs at the Crossroads: From Failures to Future Therapies

article Full Text OpenAlex

Structural and functional determination of peptide versus small molecule ligand binding at the apelin receptor

article Full Text OpenAlex

FBLN7 mediates vascular smooth muscle cell phenotype switching and vascular remodeling in hypertension

article Full Text OpenAlex

A Morphological and Behavioral Study of Demyelination and Remyelination in the Cuprizone Model: Insights into APLNR and NG2+ Cell Dynamics

article Full Text OpenAlex

Glucagon-like Peptide 1 Receptor Agonists Reduce the Risk of Venous Thromboembolism in Patients with Diabetes Irrespective of Obesity: A Propensity Score-Matched Multicenter Database Analysis

article Full Text OpenAlex

Safety, Tolerability and Pharmacokinetics of Intravenous Sodium Taurodeoxycholate, HY209, a GPCR19 Agonist Inhibiting Inflammasomal Activation

article Full Text OpenAlex

Central SGLT2 mediate sympathoexcitation in hypertensive heart failure via attenuating subfornical organ endothelial cGAS ubiquitination to amplify neuroinflammation: Molecular mechanism behind sympatholytic effect of Empagliflozin

article Full Text OpenAlex

Different supplements improve insulin resistance, hormonal functions, and oxidative stress on overweight and obese women with polycystic ovary syndrome: a systematic review and meta-analysis

review Full Text OpenAlex

The influence of PM2.5 exposure on SARS-CoV-2 infection via modulating the expression of angiotensin converting enzyme II

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TAM receptors mediate the Fpr2-driven pain resolution and fibrinolysis after nerve injury

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近5年高被引文献
Inflammation in obesity, diabetes, and related disorders

review Full Text OpenAlex 1630 FWCI372.31544824

Fibrosis in Chronic Kidney Disease: Pathogenesis and Consequences

review Full Text OpenAlex 314 FWCI40.5672497

Mechanistic insights and perspectives involved in neuroprotective action of quercetin

review Full Text OpenAlex 253 FWCI32.10671431

Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrome (ME/CFS)

article Full Text OpenAlex 248 FWCI54.6243972

Neuroprotective Effect of SGLT2 Inhibitors

review Full Text OpenAlex 229 FWCI28.43576592

GLP-1 receptor agonists (GLP-1RAs): cardiovascular actions and therapeutic potential

review Full Text OpenAlex 225 FWCI28.24363237

What is the pipeline for future medications for obesity?

review Full Text OpenAlex 224 FWCI192.43842464

Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling

article Full Text OpenAlex 218 FWCI46.86940477

Estimated Lifetime Cardiovascular, Kidney, and Mortality Benefits of Combination Treatment With SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Nonsteroidal MRA Compared With Conventional Care in Patients With Type 2 Diabetes and Albuminuria

article Full Text OpenAlex 206 FWCI69.294028

Diabetic Nephropathy: Update on Pillars of Therapy Slowing Progression

review Full Text OpenAlex 198 FWCI66.60299779