专题：14-3-3 protein interactions

This cluster of papers focuses on the structure, function, and regulation of 14-3-3 proteins, which play diverse roles in cell signaling, cancer development, phosphorylation-mediated processes, protein-protein interactions, apoptosis regulation, neurological disorders, cell cycle control, and act as molecular chaperones involved in protein stabilization.
最新文献
An evolution-conserved allosteric network in human tubulin governs paclitaxel efficacy

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The heart of the matter: a personal view of Fred Wittinghofer’s contributions to RAS biology and drug design

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Small-molecule binding and sensing with a designed protein family

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2026 ACMT Annual Scientific Meeting Abstracts – Boston, Massachusetts

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High-throughput discovery and characterisation of pentafluorobenzene sulfonamide modifiers of Aurora A kinase

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The BraBRI1-BraBZR1/BraBES1 module regulates proteoglycan- and brassinosteroid-induced thermotolerance in Pakchoi

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MhSHINE2 ‐like interacts with MhGRF3 to promote drought tolerance via modulating stomatal aperture in apple

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OsGF14d promotes oxidation of BSR-D1 to regulate rice blast resistance

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PROTAC-mediated multi-target protein degradation in Alzheimer's disease: mechanistic insights, therapeutic applications, and translational challenges

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Site-selective synthesis of C-7- and C-9-carbonate-modified paclitaxel derivatives from 1‑deoxybaccatin VI with improved affinity for mutant β tubulin and enhanced anticancer activity

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近5年高被引文献
BindingDB Entry 50022499: ZD1839 (Iressa): an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy.

article Full Text OpenAlex 933 FWCI0

Resilience to autosomal dominant Alzheimer’s disease in a Reelin-COLBOS heterozygous man

article Full Text OpenAlex 186 FWCI32.5004

NRF2: KEAPing Tumors Protected

article Full Text OpenAlex 185 FWCI14.5605

New insights into protein–protein interaction modulators in drug discovery and therapeutic advance

review Full Text OpenAlex 153 FWCI33.4279

PROTAC-DB 2.0: an updated database of PROTACs

article Full Text OpenAlex 136 FWCI10.8495

Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding

article Full Text OpenAlex 136 FWCI11.1804

Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C

article Full Text OpenAlex 134 FWCI10.7463

Structural insights into the functional roles of 14-3-3 proteins

review Full Text OpenAlex 119 FWCI9.0136

SRC kinase-mediated signaling pathways and targeted therapies in breast cancer

review Full Text OpenAlex 104 FWCI11.3007

Patient-specific Boolean models of signalling networks guide personalised treatments

article Full Text OpenAlex 97 FWCI15.2369