专题:Steroid Chemistry and Biochemistry

This cluster of papers focuses on the microbial transformation and degradation of steroids, particularly cholesterol, by various microorganisms such as Mycobacterium tuberculosis and actinobacteria. It explores the enzymatic processes involved in steroid metabolism, including the role of cholesterol oxidase and 3-ketosteroid dehydrogenases. The cluster also delves into the biotechnological applications and potential biotransformation of steroids for drug development.
最新文献
Recent Progress in the Total Synthesis of abeo -Steroids

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Recommendation of: The identification of the replicative helicase loader gene dciA within the Helicobacter pylori genome challenges current replication initiation models for this bacterium. Round#2

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Radiosynthesis and Evaluation of 18 F-Labeled Deuterated Radioligand for Positron Emission Tomography Imaging of Cholesterol 24-Hydroxylase

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Approved Steroidal Drugs (2000–2025): A Medicinal Chemistry Perspective

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Scalable and Stereoselective C–H Bond Hydroxylation of Steroids Using a Designer Heme-Thiolate Peroxygenase Biocatalyst

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Soil-specific functional perturbations of microbiota induced by 17β-estradiol: An integrated microbiomics and metabolomics analysis

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Diversity analysis of endohyphal bacteria in oil-producing fungi inhabiting arid environments

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21-hydroxypregna-4,6-diene-3,12,20-trione : NP0032609

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Green Drug Discovery: Leveraging Biodiversity for Sustainable Pharmaceutical Solutions

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2α-Hydroxy-D-homo-17a-oxaandrosta-4,6-diene-3,17-dione : NP0352090

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近5年高被引文献
The Bioavailability and Biological Activities of Phytosterols as Modulators of Cholesterol Metabolism

review Full Text OpenAlex 160 FWCI33.3764

β-Sitosterol as a Promising Anticancer Agent for Chemoprevention and Chemotherapy: Mechanisms of Action and Future Prospects

review Full Text OpenAlex 125 FWCI40.2993

Macrophage-Derived 25-Hydroxycholesterol Promotes Vascular Inflammation, Atherogenesis, and Lesion Remodeling

article Full Text OpenAlex 102 FWCI20.4923

Efficient heterologous expression of cytochrome P450 enzymes in microorganisms for the biosynthesis of natural products

review Full Text OpenAlex 98 FWCI7.8961

The Concise Guide to PHARMACOLOGY 2023/24: Nuclear hormone receptors

article Full Text OpenAlex 88 FWCI27.0423

Small-molecule allosteric inhibitors of GPX4

article Full Text OpenAlex 83 FWCI12.7772

Biotransformation Enables Innovations Toward Green Synthesis of Steroidal Pharmaceuticals

review Full Text OpenAlex 64 FWCI4.9751

A Chemoenzymatic Strategy for the Synthesis of Steroid Drugs Enabled by P450 Monooxygenase-Mediated Steroidal Core Modification

article Full Text OpenAlex 62 FWCI4.7724

Rationally Controlling Selective Steroid Hydroxylation via Scaffold Sampling of a P450 Family

article Full Text OpenAlex 61 FWCI9.6983

Helicobacter pylori Biofilm-Related Drug Resistance and New Developments in Its Anti-Biofilm Agents

article Full Text OpenAlex 59 FWCI11.5537