专题：Biological Stains and Phytochemicals

This cluster of papers focuses on the biosynthesis and pharmacological activities of medicinal natural products, particularly emphasizing the antioxidant, anti-inflammatory, antimicrobial, and antitumor properties of compounds such as cassane diterpenoids and flavonoids. The research also delves into the mechanisms of action, including the involvement of heme oxygenase-1 in mediating certain effects.
最新文献
Phytochemical Investigation and Herbal Cream Development from Acalypha Fruticosa Forssk Ethanolic Extract

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Immunofluorescence staining –Paraffin sections v1

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<i>In </i><i>S</i><i>ilico</i> ADMET, Molecular Docking of Antimicrobial Compounds from Leaves of <i>Xeroderris </i><i>s</i><i>tuhlmannii</i> (Taub.) Mendonca & E.P. Sousa (<i>Fabaceae</i>)

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Bioefficacy of Caesalpinia bonduc (L.) Roxb. from Bhilai region against pathogenic clinical and MTCC microbial isolates

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Potential of natural dyes from non-traditional flowers for textile application– A comprehensive review

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Background: Asthma is a chronic inflammatory respiratory disease affecting over 300 million individuals globally, with limited treatment efficacy and significant adverse effects associated with conventional pharmacotherapy. Plant-based therapeutic agents have emerged as promising alternatives warranting systematic evaluation. Objective: This study evaluated the anti-asthmatic, antihistaminic, and bronchoprotective potential of ethanolic leaf extract of Caesalpinia pulcherrima (Caesalpiniaceae) through complementary in vitro and in vivo approaches in guinea pig models. Methods: In vitro antihistaminic activity was assessed using histamine-induced contraction in isolated guinea pig ileum preparations, with responses compared against chlorpheniramine maleate (standard control). In vivo bronchoprotective efficacy was evaluated in an acute histamine aerosol-induced bronchospasm model in guinea pigs. Test groups received vehicle (0.1% carboxymethyl cellulose), chlorpheniramine maleate (2 mg/kg), or ethanolic leaf extract (200 and 400 mg/kg, p.o.). Preconvulsive dyspnoea time (PCT) was measured at baseline, 1 hour, 4 hours, and 24 hours post-drug administration. Percentage protection was calculated and analyzed. Results: In vitro studies demonstrated dose-dependent inhibition of histamine-induced ileal contractions by the extract, achieving 74.05% inhibition at maximum histamine concentration (3.2 ml), comparable to chlorpheniramine effects. In vivo studies showed significant bronchoprotection with peak efficacy at 4 hours post-administration; the 400 mg/kg extract dose yielded 67.44% protection versus 73.73% for chlorpheniramine maleate. The 400 mg/kg extract group exhibited preconvulsive dyspnoea time of 21.50 ± 0.43 seconds at 4 hours, significantly extended compared to vehicle control (p<0.001), demonstrating protection comparable to the standard antihistamine. Conclusion: Ethanolic leaf extract of Caesalpinia pulcherrima demonstrates significant antihistaminic activity and bronchoprotective efficacy in guinea pig models of acute histamine-induced bronchospasm, providing pharmacological validation of its ethnomedicinal use in respiratory disorders. The findings support further mechanistic investigation and phytochemical characterization to identify active constituents and elucidate molecular pathways underlying these therapeutic effects.

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APPLICATION OF BUTTERFLY PEA FLOWERS ON ECO NATURAL DYEING PROCESS FOR KNITTED COTTON FABRIC

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Assessment of Toxicity in the Extract of the Herb Betonica

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Anti-Asthmatic Activity of Caesalpinia pulcherrima in Guinea Pigs

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Anti-Asthmatic Activity of Caesalpinia pulcherrima in Guinea Pigs

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近5年高被引文献
Glyoxal fixation: An approach to solve immunohistochemical problem in neuroscience research

article Full Text OpenAlex 74 FWCI16.44837806

Bioactive molecules in wood extractives: Methods of extraction and separation, a review

review Full Text OpenAlex 68 FWCI7.54782115

A Comprehensive Review on Bioactive Compounds Found in Caesalpinia sappan

review Full Text OpenAlex 56 FWCI17.37574545

A review of plant-based natural dyes in leather application with a special focus on color fastness characteristics

review Full Text OpenAlex 50 FWCI10.49620514

Caesalpinia crista Seeds Mediated Green Synthesis of Zinc Oxide Nanoparticles for Antibacterial, Antioxidant, and Anticancer Activities

article Full Text OpenAlex 45 FWCI9.17010093

Wound Healing Efficacy of Rosuvastatin Transethosomal Gel, I Optimal Optimization, Histological and In Vivo Evaluation

article Full Text OpenAlex 43 FWCI5.2255176

Corrosion inhibition properties of Camellia chrysantha flower extract for Q235 in 1 M HCl solution

article Full Text OpenAlex 35 FWCI4.69052832

Network Pharmacology Study to Reveal the Potentiality of a Methanol Extract of Caesalpinia sappan L. Wood against Type-2 Diabetes Mellitus

article Full Text OpenAlex 33 FWCI6.72474068

In Vitro Synergistic Inhibitory Effects of Plant Extract Combinations on Bacterial Growth of Methicillin-Resistant Staphylococcus aureus

article Full Text OpenAlex 30 FWCI9.30843506

Advancing PHBV Biomedical Potential with the Incorporation of Bacterial Biopigment Prodigiosin

article Full Text OpenAlex 29 FWCI8.43804422