专题：Nuclear Receptors and Signaling

This cluster of papers explores the Nurr1/CoREST pathway and its role in protecting dopaminergic neurons from inflammation-induced death, with implications for neurodegenerative diseases such as Parkinson's. The research covers topics such as mitochondrial targeting, nuclear receptors, transcriptional regulation, and apoptosis.
最新文献
Sex-specific associations of gene expression with Alzheimer’s disease neuropathology and ante-mortem cognitive performance

article Full Text OpenAlex

Pharmacologic NLRP3 Inhibition Modulates Parkinson’s Disease-Associated Microglial Transcriptomic Signatures and Mitigates α-Synuclein–Triggered Neurodegeneration

preprint Full Text OpenAlex

Global and Regional Patterns of Parkinson’s Disease: Temporal Trends, Inequality Gaps, and Projections to 2040

preprint Full Text OpenAlex

Disease-associated microglia in neurodegenerative diseases: Friend or foe?

review Full Text OpenAlex

Investigation of Genetic Variations in APLN and APLNR Genes and Their Potential Role in Cardiovascular Diseases

article Full Text OpenAlex

GFRAL-Fc disarms GDF15 to reprogram tumor immunity and amplify PD-1 efficacy in hepatocellular carcinoma

article Full Text OpenAlex

Targeting GSK-3β to Modulate the Wnt Pathway: A Promising Neuroprotective Strategy for Alzheimer’s Disease

article Full Text OpenAlex

Indole-3-propionic acid function through PXR and AhR, molecular signaling pathways, and antitoxic role in underlying diseases

review Full Text OpenAlex

GPX2 induces macrophage M2 polarization through the MIF signaling pathway to promote colorectal cancer progression

article Full Text OpenAlex

Microglia-specific regulation of lipid metabolism in Alzheimer’s disease revealed by microglial depletion in 5xFAD Mice

article Full Text OpenAlex

近5年高被引文献
Molecular docking as a tool for the discovery of molecular targets of nutraceuticals in diseases management

review Full Text OpenAlex 850 FWCI262.61702319

Signaling pathways and targeted therapy for myocardial infarction

review Full Text OpenAlex 703 FWCI85.16385732

The pathogenesis of Parkinson's disease

review Full Text OpenAlex 629 FWCI480.09356924

Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study

article Full Text OpenAlex 592 FWCI180.94739336

Multiple sclerosis progression: time for a new mechanism-driven framework

review Full Text OpenAlex 508 FWCI102.3933441

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

article Full Text OpenAlex 350 FWCI65.69567101

Trial of Prasinezumab in Early-Stage Parkinson’s Disease

article Full Text OpenAlex 349 FWCI59.4284606

Signaling pathways in Parkinson’s disease: molecular mechanisms and therapeutic interventions

review Full Text OpenAlex 345 FWCI72.98518758

FSH blockade improves cognition in mice with Alzheimer’s disease

article Full Text OpenAlex 315 FWCI42.62188662

Long-term efficacy and safety of inclisiran in patients with high cardiovascular risk and elevated LDL cholesterol (ORION-3): results from the 4-year open-label extension of the ORION-1 trial

article Full Text OpenAlex 276 FWCI138.52729068